The culprit lesion for a STEMI (ST elevation myocardial infarction) is total closure of a coronary artery.
There is no blood flow to the heart muscle.
Image source: Millennium and Key Pharm.
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Image source: Millennium Pharm and Key Pharm
This angiogram shows total occlusion of the right coronary artery.
This ECG show ST elevation (tombstones) in the inferior leads consistent with a STEMI